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. 2019 Jun 20;2019(6):CD012673. doi: 10.1002/14651858.CD012673.pub2

Chen 1997.

Methods Multicentre, open, randomised clinical trial
Participants Included participants: cirrhosis (implied not stipulated) and oesophageal varices with no history of previous upper gastrointestinal bleeding (n = 156) (Table 4)
Age: not reported
Proportion of men: not reported
Aetiology of cirrhosis: not reported
Child‐Pugh score: not reported
Presence of ascites: not reported
Interventions Intervention comparison:
Band ligation (n = 80) (Table 5)
  • Participants who bled during follow‐up were banded, if possible


No intervention (n = 76)
  • Participants who bled during follow‐up were banded if possible


Cointerventions: no information provided
Outcomes Outcomes included in the meta‐analyses
  • Mortality

  • Upper gastrointestinal bleeding

  • Variceal bleeding

  • Serious adverse events

Inclusion period Not provided
Country Taiwan
Duration of follow‐up Median 32 months
Notes Publication status: abstract; further information sought from the authors but not forthcoming
  • Participants in both groups were well matched in terms of demographic and clinical characteristics


For‐profit funding: not described
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described
Allocation concealment (selection bias) Unclear risk Not described
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Open trial without blinding
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Open trial without blinding
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk No information provided on the number of participants with missing outcome data (losses to follow‐up or withdrawals)
Selective reporting (reporting bias) Low risk Clinically relevant outcomes are reported. We did not have access to the trial protocol
Other bias Low risk No other biases identified
Overall bias assessment (mortality) High risk High risk of bias
Overall bias assessment (non‐mortality outcomes) High risk High risk of bias