Table 1. Overview of the model parameters.

Model Input	Source	Treatment specific?	Time invariant?	Distribution used in the PSA*
Initial distribution and transition probabilities among NYHA classes and death probabilities	TEN-HMS trial [37]	Yes	No	Dirichlet
Resource use (hospital, emergency room, nurse visit, GP, etc.) associated with each NYHA class	TEN-HMS trial [37]	Yes	Yes	Gamma
Utility values associated with each NYHA class	TEN-HMS trial [37] and Dutch utility weights [43]	No	Yes	Gamma
The unit cost for each type of resource use	Dutch cost guideline [44]	No	Yes	Gamma
Intervention/ comparator costs	Assumptions, treatment guidelines [45], TEN-HMS [37]	Yes	No	N/A

*PSA = Probabilistic Sensitivity Analysis