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Glutaminolysis, the metabolic conversion of glutamine to glutamate, aspartate and alanine, represents an alternative pathway to supply the mitochondrial citric acid cycle with a surplus of α-ketoglutarate. As this pathway is preferentially used by proliferating tissue, glutaminolysis measured as (cAla+cAsp+cGlu)/cGln is increased in tumor tissue.[22] Metabolites determined in this study are marked in grey.
