Table 1. Patient characteristics of AMD cases and control individuals.
| AMD cases (n = 72) |
Control individuals (n = 72) |
P-value | ||
|---|---|---|---|---|
| Sex | Male | 26 (36.1%) | 28 (38.9%) | |
| Female | 46 (63.9%) | 44 (61.1%) | 0.73 | |
| Age (mean years ±SD) | 72.65±7.30 | 70.64±5.27 | 0.06 | |
| Smoking status | Never | 34 (47.2%) | 37 (51.4%) | |
| Past | 38 (52.8%) | 35 (48.6%) | ||
| Current | 0 (0%) | 0 (0%) | 0.62 | |
| BMI (kg/m2) | <20 | 3 (4.2%) | 3 (4.2%) | |
| 20–25 | 35 (48.6%) | 29 (40.3%) | ||
| 25–30 | 28 (38.9%) | 33 (45.8%) | ||
| >30 | 6 (8.3%) | 7 (9.7%) | 0.79 | |
| Diabetes Mellitus* | Absent | 64 (90.1%) | 64 (91.4%) | |
| Present | 7 (9.9%) | 6 (8.6%) | 0.79 | |
| Diet | Regular diet | 65 (94.2%) | 66 (95.7%) | |
| Vegetarian diet** | 4 (5.8%) | 3 (4.3%) | 0.70 | |
| Complement activation (mean±SD***) | C3d/C3 ratio | 1.54±0.40 | 1.47±0.44 | 0.37 |
| CFH, rs1061170 (C) | MAF | 44.4 | 45.1 | 0.93 |
| ARMS2, rs10490924 (T) | MAF | 34.7 | 32.6 | 0.74 |
*Self-reported diagnosis
**Vegetarian diet when participant indicated to (almost) never eat fish and red meat
***For the purpose of analyses data was transformed to the natural logarithm
Abbreviations: SD, standard deviation; BMI, body mass index; MAF, minor allele frequency.