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. Author manuscript; available in PMC: 2019 Oct 5.
Published in final edited form as: ACS Catal. 2018 Sep 5;8(10):9292–9297. doi: 10.1021/acscatal.8b03014

Table 1.

Evaluation of Ligands for C(sp3)–H Arylation of Weinreb Amidea,b

graphic file with name nihms-1035408-t0002.jpg
a

Conditions: 1a (0.1 mmol), Pd(OAc)2 (10 mol%), Ligand (12 mol%), methyl 4-iodobenzoate (0.2 mmol), AgOAc (0.2 mmol), HFIP (0.5 mL), 70 °C, under air, 24 h.

b

The yield was determined by 1H NMR analysis of the crude product using CH2Br2 as the internal standard.

c

80 °C.