Skip to main content
. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Invest Dermatol. 2018 Oct 12;139(2):380–390. doi: 10.1016/j.jid.2018.08.026

Figure 6. Increased mechanical dissociation of keratinocyte monolayers from OS and EK subjects with PERP mutations demonstrates defective intercellular adhesion.

Figure 6.

(a) Images of keratinocyte monolayers after repeated pipetting (20 or 40 repetitions) show increased stress- induced fragmentation in both probands. (b) Particle counts quantify the significantly increased dissociation of keratinocyte monolayers in probands. For controls for Subjects 1 and 5, keratinocytes were derived from biopsies from the abdomen of a 22 year old and the shoulder of a 28 year old, respectively.