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Wee1 inhibits proliferation (red arrow) by inactivating CDK1/CyclinB1 complex. microRNA-294 delivery to the infarcted heart represses Wee1 activates CDK1/Cyclin B1 complex (Black arrows) through dephosphorylation of CDK1 that promotes cell cycle reentry together with a proliferative phenotype that includes high energy generation and survival ultimately augmenting cardiomyocyte replenishment in the heart after myocardial infarction.
