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. 2019 Apr 26;79(5):479–496. doi: 10.1002/dneu.22676

Figure 5.

Figure 5

Loss of neuronal progenitors and prdl‐a/prdl‐a expression in aging H. oligactis. (A) Decrease in hypostome size in Ho_CS and Ho_CR animals maintained at 18°C or 10°C for 35 days. (B) Transient decrease in interstitial cycling cells in Ho_CS. (C) Apical expression of prdl‐a in Ho_CS and Ho_CR animals maintained at 18°C or 10°C for 45 days. (D) Immunodetection of the homeoprotein prdl‐a in Ho_CS and Ho_CR animals maintained at 18°C or taken 44 days after transfer to 10°C. Scale bars: 20 µm (left panels) and 10 µm (right panels). Note the progressive decrease in the number of prdl‐a expressing cells in aging Ho_CS when compared to Ho_CR maintained in the same conditions.