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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Pain. 2019 Jul;160(7):1594–1605. doi: 10.1097/j.pain.0000000000001541

Figure 4.

Figure 4.

S1back seed voxel connectivity is altered by exacerbated low back pain in cLBP patients. A. Compared to healthy controls, cLBP patients in an exacerbated low back pain state demonstrated increased S1back connectivity to several salience network brain regions: anterior insular cortex (aIns), dorsolateral prefrontal cortex (dlPFC), and anterior temporoparietal junction (aTPJ). Note that healthy controls did not perform any maneuvers. B. Compared to cLBP patients at baseline, following physical maneuvers, S1back seed voxel connectivity was increased to anterior temporoparietal junction (aTPJ, a salience network subregion). C. S1back connectivity to specific salience network brain regions was increased in cLBP patients compared to healthy adults. Note: # = significant with whole brain voxelwise analysis with cluster-size correction for multiple comparisons.