Table 3. Changes in Ki-67 expression with metformin treatment did not correlate with changes in expression of markers of the PI3K–Akt–mTOR or insulin signaling pathways within endometrial tumors.

Difference in	pAkt expression	pS6 expression	p4EBP1 expression	pACC expression	pIR expression	pIGF1R expression	Serum insulin	HOMA-IR
Ki-67 expression	−0.18, 0.32	−0.11, 0.54	0.19, 0.27	−0.08, 0.63	−0.19, 0.27	0.17, 0.32	0.22, 0.15	0.22, 0.14

NOTE: Results are presented as Pearson correlation coefficient, P value.