Table 3.
Association analyses between hypothalamic volume and CAPs, cortisol and melatonin.
| Side | k |
Peak voxel |
||
|---|---|---|---|---|
| tscore | MNI coordinates | |||
| CAPs | ||||
| Negative association with CAPs in premanifest HD | B | 204 | 3.16 | -3 2 -7 |
| Cortisol | ||||
| Negative association with cortisol output in premanifest HD | L | 161 | 2.54 | -10 1 -4 |
| Group by cortisol output interaction | L | 186 | 2.32 | -10 1 -4 |
| Melatonin | ||||
| Positive association with melatonin output in healthy controls | L | 161 | 2.67 | -10 1 -6 |
| Group by melatonin output interaction | L | 201 | 2.41 | -6 2 -8 |
Group differences were analysed using two-sample t-tests.
*Results are significant at p < 0.05, uncorrected.
k = No. of voxels; MNI = Montreal Neurological Institute; HD = Huntington's disease; B = bilateral; L = left.