Fig. 1.

Myogenic lineage progression and expression profile of key myogenic regulators. a Schematic illustration of the myogenic lineage progression. Satellite cells are activated, e.g., due to injury, start to proliferate, thereby generating myogenic progenitor cells. Upon differentiation, myogenic progenitor cells differentiate into myocytes, which fuse to form myotubes and mature to become myofibers, the contractile unit of skeletal muscle. b Expression profile of key modulators of myogenic lineage progression