Table 2.
Cox proportional hazards model for recurrence-free and overall survival
| Variables | Recurrence-free survival | Overall survival | |||||
|---|---|---|---|---|---|---|---|
| RR | 95% CI | p value | RR | 95% CI | p value | ||
| A univariate analysis | |||||||
| Age | > 50 versus ≤ 50 | 1.16 | 0.58–2.59 | 0.69 | 1.45 | 0.64–3.88 | 0.40 |
| Tumor size | > 2 cm versus ≤ 2 cm | 2.65 | 1.41–5.14 | 0.0023 | 2.33 | 1.16–4.84 | 0.018 |
| Nodal status | Positive versus negative | 2.75 | 1.48–5.20 | 0.0015 | 2.26 | 1.12–4.56 | 0.023 |
| Nuclear grade | 3 versus 1 and 2 | 1.03 | 0.52–2.17 | 0.94 | 0.69 | 0.34–1.45 | 0.32 |
| Ki-67 | > 30% < versus ≤ 30% | 1.61 | 0.57–6.70 | 0.41 | 0.75 | 0.31–2.23 | 0.58 |
| CD8 | Positive versus negative | 1.52 | 0.81–2.96 | 0.20 | 1.10 | 0.55–2.26 | 0.78 |
| PD-L1 on TC | Positive versus negative | 0.84 | 0.43–1.58 | 0.60 | 0.62 | 0.28–1.27 | 0.20 |
| Adjuvant treatment | Chemo. versus no treat. | 0.80 | 0.42–1.57 | 0.51 | 0.43 | 0.22–0.87 | 0.02 |
| T-bet | Positive versus negative | 0.54 | 0.22–1.14 | 0.11 | 0.36 | 0.11–0.92 | 0.032 |
| B Multivariate analysis | |||||||
| Tumor size | > 2 cm versus ≤ 2 cm | 2.73 | 1.29–6.19 | 0.0084 | 2.18 | 1.00–5.05 | 0.05 |
| Nodal status | Positive versus negative | 3.17 | 1.50–6.92 | 0.0024 | 2.78 | 1.26–6.24 | 0.012 |
| Nuclear grade | 3 versus 1 and 2 | 0.99 | 0.42–2.58 | 0.98 | 0.58 | 0.25–1.43 | 0.24 |
| Ki-67 | > 30% < versus ≤ 30%) | 1.79 | 0.62–6.02 | 0.30 | 1.90 | 0.70–5.78 | 0.22 |
| CD8 | Positive versus negative | 2.00 | 0.95–4.33 | 0.07 | 1.52 | 0.69–3.32 | 0.30 |
| Adjuvant treatment | Chemo. versus no treat. | 0.67 | 0.32–1.43 | 0.29 | 0.39 | 0.18–0.85 | 0.018 |
| T-bet | Positive versus negative | 0.36 | 0.12–0.94 | 0.037 | 0.30 | 0.07–0.95 | 0.039 |
Bold value represents that P value was significant
HR hazard ratio, CI confidence interval, TC tumor cells, Chemo chemotherapy, No treat no treatment