Table 3.

Overview of sensitivity analyses

Analysis	Pool	Number of studies	Correlation	STE
Main analysis	All identified studies	16	0.72	0.60
Sensitivity analysis 1	HER2 status
	(a) Studies reporting HER2 status of patients	13	0.68	0.45
	(b) Studies not reporting HER2 status	3	n. c.a	0.86
Sensitivity analysis 2	Line of treatment
	(a) Studies only including first-line patients	6	0.82	0.75
	(b) Studies including pretreated patients or patients in various lines	10	0.71	n.c.b
Sensitivity analysis 3	Therapy option
	(a) Studies comparing a combination therapy with a mono therapy (combi vs. mono)	12	0.65	0.47
	(b) Studies comparing two monotherapies (mono vs. mono)	4	0.99	0.84

HER2 human epidermal growth factor receptor 2, n.c. not calculable

^aIn order to calculate a correlation coefficient, at least 4 studies are needed

^bUpper confidence limit of HR_OS > 1 for any value of HR_PFS