Table 2.
Mean levels of biomarkers of all study patients and of patients with and without CAD at the three time points (pre, post, and day 1)
| Biomarker | Total patientsa | CAD patientsb | Non-CAD patientsc | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Pre | Post | Day 1 | Pre | Post | Day 1 | Pre | Post | Day 1 | |
| • Biomarker of myocardial injury | |||||||||
| hs-TnT (ng/L) | 16.10 ± 2.42 | 15.28 ± 2.28 | 16.43 ± 2.45 | 17.91 ± 3.38 | 16.98 ± 3.22 | 18.34 ± 3.47 | 13.12 ± 3.18 | 12.47 ± 3.02 | 13.29 ± 3.23 |
| • Biomarkers of systemic inflammation | |||||||||
| hs-CRP (mg/L) | 4.16 ± 0.61 | 3.96 ± 0.59 | 9.69 ± 1.44 | 4.53 ± 0.86 | 4.38 ± 0.83 | 9.80 ± 1.85 | 3.56 ± 0.86 | 3.28 ± 0.80 | 9.51 ± 2.31 |
| Fibrinogen (mg/l) | 3.29 ± 0.49 | 3.22 ± 0.48 | 3.54 ± 0.53 | 3.20 ± 0.60 | 3.16 ± 0.60 | 3.43 ± 0.65 | 3.45 ± 0.84 | 3.35 ± 0.81 | 3.72 ± 0.90 |
| IFN-γ (pg/ml) | 2.36 ± 0.35 | 2.40 ± 0.36 | 7.59 ± 1.13 | 2.37 ± 0.45 | 2.46 ± 0.47 | 8.06 ± 1.52 | 2.34 ± 0.57 | 2.30 ± 0.56 | 6.82 ± 1.66 |
| TNF-α (pg/ml) | 10.52 ± 1.57 | 10.31 ± 1.54 | 11.37 ± 1.69 | 10.76 ± 2.03 | 10.40 ± 1.97 | 11.61 ± 2.19 | 10.12 ± 2,46 | 10.15 ± 2.46 | 10.99 ± 2.67 |
| IL-1β (pg/ml) | 0.44 ± 0.07 | 0.39 ± 0.06 | 0.47 ± 0.07 | 0.50 ± .0.09 | 0.39 ± 0.07 | 0.49 ± 0.09 | 0.33 ± 0.08 | 0.39 ± 0.09 | 0.44 ± 0.11 |
| IL-6 (pg/ml) | 1.96 ± 0.29 | 1.89 ± 0.28 | 3.92 ± 0.58 | 2.08 ± 0.39 | 1.99 ± 0.38 | 4.15 ± 0.78 | 1.77 ± 10.43 | 1.73 ± 0.18 | 3.54 ± 0.86 |
| IL-8 (pg/ml) | 4.25 ± 0.63 | 5.56 ± 0.83 | 6.51 ± 0.97 | 4.51 ± 0.85 | 5.23 ± 0.99 | 7.35 ± 1.39 | 3.83 ± 0.93 | 6.10 ± 2.09 | 5.13 ± 1.25 |
| IL-10 (pg/ml) | 7.87 ± 1.17 | 8.28 ± 1.23 | 8.52 ± 1.27 | 7.47 ± 1.41 | 8.07 ± 1.53 | 8.14 ± 1.54 | 8.53 ± 2.07 | 8.62 ± 2.09 | 9.15 ± 2.22 |
| IL-12 (pg/ml) | 7.33 ± 1.09 | 6.83 ± 1.02 | 7.45 ± 1.11 | 4.41 ± 0.83 | 4.25 ± 0.80 | 5.22 ± 0.99 | 12.14 ± 2.95 | 11.10 ± 2.69 | 11.13 ± 2.70 |
| • Biomarker of endotoxemia (LPS endotoxin) | |||||||||
| LPS (LAL) (EU/ml) | 1.02 ± 0.15 | 1.09 ± 0.16 | 1.41 ± 0.21 | 0.98 ± 0.19 | 1.05 ± 0.20 | 1.45 ± 0.22 | 1.08 ± 0.26 | 1.17 ± 0.28 | 1.34 ± 0.33 |
IL interleukin IFN-γ interferon-γ, hs-TnT highly sensitive troponin T, hs-CRP highly sensitive C-reactive protein, LPS lipopolysaccharide,TNF-α tumor necrosis factor-α
Values = mean ± SEM
an = 45 for all except for fibrinogen = 43
bn = 28 for all except for fibrinogen = 27
cn = 17 for all except for fibrinogen = 16