Table 5.
Mean levels of biomarkers of all study patients and of patients with and without hs-TnT rise at the three time points (pre, post, and day 1)
| Biomarker | hs-TnT rise patientsa | hs-TnT non-rise patientsb | ||||
|---|---|---|---|---|---|---|
| Pre | Post | Day 1 | Pre | Post | Day 1 | |
| • Biomarkers of systemic inflammation | ||||||
| hs-CRP (mg/L) | 5.43 ± 1.03 | 5.14 ± 0.97 | 10.53 ± 1.99 | 2.07 ± 0.50 | 2.03 ± 0.49 | 8.31 ± 2.02 |
| Fibrinogen (mg/l) | 3.34 ± 0.63 | 3.29 ± 0.62 | 3.64 ± 0.69 | 3.22 ± 0.78 | 3.13 ± 0.76 | 3.38 ± 0.82 |
| IFN-γ (pg/ml) | 2.35 ± 0.44 | 2.38 ± 0.45 | 8.69 ± 1.64 | 2.37 ± 0.58 | 2.44 ± 0.59 | 5.78 ± 1.40 |
| TNF-α (pg/ml) | 10.97 ± 2.07 | 10.44 ± 1.97 | 12.15 ± 2.30 | 9.77 ± 2.37 | 10.09 ± 2.45 | 10.09 ± 2.45 |
| IL-1β (pg/ml) | 0.50 ± 0.09 | 0.42 ± 0.08 | 0.41 ± 0.08 | 0.33 ± 0.08 | 0.35 ± 0.08 | 0.57 ± 0.14 |
| IL-6 (pg/ml) | 2.02 ± 0.38 | 1.89 ± 0.36 | 3.92 ± 0.74 | 1.88 ± 0.46 | 1.89 ± 0.46 | 3.91 ± 0.95 |
| IL-8 (pg/ml) | 4.71 ± 0.89 | 5.37 ± 1.02 | 6.88 ± 1.30 | 3.50 ± 0.85 | 5.88 ± 1.43 | 5.90 ± 1.43 |
| IL-10 (pg/ml) | 6.63 ± 1.25 | 6.65 ± 1.26 | 7.23 ± 1.37 | 9.91 ± 2.41 | 10.97 ± 2.66 | 10.66 ± 2.59 |
| IL-12 (pg/ml) | 4.30 ± 0.81 | 4.02 ± 0.76 | 5.03 ± 0.95 | 12.33 ± 2.99 | 11.46 ± 2.78 | 11.45 ± 2.78 |
| • Biomarker of endotoxemia (LPS endotoxin) | ||||||
| LPS (LAL) (EU/ml) | 0.98 ± 0.19 | 1.09 ± 0.21 | 1.44 ± 0.27 | 1.08 ± 0.26 | 1.10 ± 0.27 | 1.36 ± 0.33 |
IL interleukin, IFN-γ interferon-γ, hs-TnT highly sensitive troponin T, hs-CRP highly sensitive C-reactive protein, LPS lipopolysaccharide, TNF-α tumor necrosis factor-α
Values = mean ± SEM
an = 28 for all except for fibrinogen = 27
bn = 17 for all except for fibrinogen = 16