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. 2019 Jun 20;10(7):487. doi: 10.1038/s41419-019-1716-9

Fig. 7. Infliximab provides protective effects against BBB disruption and I/R injury after stroke.

Fig. 7

a Experimental scheme. b–d Endogenous protein expression of p-RIP1/RIP1 and p-MLKL/MLKL in ischemic lateral cortex after tMCAO (3 day) from different groups. n = 6; *P < 0.05 vs. Sham group; **P < 0.01 vs. control group; #P < 0.05 vs. vehicle group. e–g Representative MRI post-contrast T1-SE images and statistical BBB permeability represented by T1SI-diff and T1SI-diff × PBV of rat brains from each group. n = 6; *P < 0.001 vs. Sham group; #P < 0.01 vs. vehicle group. h, i Evans blue leakage of rat brains in coronal sections (h) and extravasation (μg/g tissue) (i) from each group. n = 3; *P < 0.001 vs. Sham group; #P < 0.01 vs. vehicle group. j–m Representative images and statistical results of TTC and MRI T2-SE imaging. n = 6 for MRI, n = 3 for TTC staining; #P < 0.01 vs. vehicle group. k) Modified neurological severity score from day 0 to day 7 after tMCAO in different groups. n = 6; *P < 0.05 vs. vehicle group