Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 20;9:8918. doi: 10.1038/s41598-019-45509-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Adiponectin/ACRP30 alleviates aberrant GSK3β and NF-κB signalling in the 5XFAD mouse hippocampus. (a) GSK3β activation and cleaved caspase 3 protein levels were increased in 5XFAD mouse hippocampus compared with those in wild-type mice; these were alleviated by adiponectin/ACRP30 treatment for 10 min and 2 h. (b) Phosphorylated p65 (p-p65) protein levels were significantly increased in 5XFAD mouse hippocampus compared with those in the control; this increase was suppressed by adiponectin/ACRP30 treatment for 10 min and 2 h. (c) Analysis of IL-1β, IL-6 and IL-10 expression by Western blotting (n = 4 in each group). Data are expressed as means ± SEMs. *p < 0.05, **p < 0.001, ***p < 0.0001; a.10 and a.2 indicate 2.7 nM adiponectin/ACRP30 treatment for 10 min and 2 h, respectively; C, 5XFAD control mouse hippocampus.