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. 2019 Jun 20;9:8872. doi: 10.1038/s41598-019-45467-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SCFAs inhibit C. albicans growth in vitro. Growth of C. albicans strains SC 5314 (a) and ATCC 10231 (b) in the presence of SCFAs or in pH-adjusted RPMI media determined by spectrophotometer analysis at an optical density of 600 nm after 24 and 48 hours of incubation. Experiment was repeated three times and the three combined replicates were shown here with total n = 9 for each group. Data is represented as means ± SEM. Statistical significance was evaluated using student’s t-test and P values (* ≤ 0.05, ** ≤ 0.01) were considered as significant. Significance is shown only for data points that exhibited significant decreases in growth compared to respective controls. Significance for pH-adjusted RPMI values was assessed using pH 7.00 as the comparative data set; significance for SCFA-treated conditions was assessed using respective pH controls for each SCFA condition in statistical analyses. Significance (**) for acetic acid (50 mM), butyric acid (12.5 mM and 25 mM), and propionic acid (25 mM) indicates p ≤ 0.01 at both 24 and 48 hours in both strains.