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Dose- and time-dependent effects of CM-304 (purple diamonds) or AZ-66 (blue triangles) after a 45 mg/kg i.p. administration in the mouse rotarod assay. U50,488 (orange circles, 10 mg/kg, i.p.) is added as a positive control. * = significantly different than either vehicle effect (gray diamonds), p < 0.05; two-way ANOVA w/Dunnett’s post hoc test; N = 8–12 mice/treatment.
