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CM-304 (45 mg/kg/d, i.p.; N = 34) did not demonstrate place-conditioning preference (as did morphine, N = 17) or aversion, whereas AZ-66 (45 mg/kg/d, i.p., N = 19) demonstrated CPA similar to U50,488 (N = 28) in the mouse conditioned place preference assay. * = post-conditioning response (striped bars) significantly different from matching pre-CPP response (matching open bars), p < 0.05; two-way ANOVA w/Sidak’s post hoc test.
