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Dose- and time-dependent antiallodynic activity of morphine (blue circles), gabapentin (green hexagons), or the sigma-receptor antagonist E52862 after i.p. administration in the mouse chronic constriction injury (CCI) assay. * = significantly greater than vehicle effect (black circles) at matching time points, p < 0.05; two-way ANOVA w/Tukey’s post hoc test. N = 10–12 mice/point.
