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. 2019 Jun 14;10:678. doi: 10.3389/fphar.2019.00678

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Copyright © 2019 Cirino, Eans, Medina, Wilson, Mottinelli, Intagliata, McCurdy and McLaughlin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dose- and time-dependent antiallodynic activity of (A) CM-304 (diamonds) and (B) AZ-66 (squares) in the mouse chemotherapy-induced neuropathy (CISN) assay. Morphine (blue circles) and gabapentin (green hexagons, 60-min pretreatment) are included as positive controls; vehicle (saline; black circles) is included as a negative control. * = significantly greater than vehicle effect, p < 0.05; two-way ANOVA w/Tukey’s post hoc test. N = 9–10 mice treated with a single dose of sigma receptor antagonists, six mice treated with morphine, nine mice treated with gabapentin, and eight mice treated with saline alone.