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Dose- and time-dependent respiratory effects of i.p. administration of (A) CM-304 or (B) AZ-66 evaluated in the CLAMS assay with C57BL6/J mice. Morphine (30 mg/kg, i.p.) included as a positive control. * = significantly different from vehicle effect (dashed line), p < 0.05; two-way ANOVA w/Dunnett’s post hoc test. N = 10–20 mice/group.
