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. 2019 Jun 20;9:8993. doi: 10.1038/s41598-019-45299-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of therapeutic sEH inhibition on renal histology findings in lupus prone NZB/W F1 mice. Representative kidney histology in the prophylactic group after four weeks of exposure to PEG (A) or sEHI (B; HE staining, 200x magnification). (C) Example histology from the treatment group after three weeks of exposure to PEG. Note the destroyed glomeruli (PAS staining, 200x magnification). (D) Kidney sample after 3-weeks exposure to sEHI, showing less severe glomerular changes than for the PEG group (PAS staining, 200x magnification). Scale bars = 100 µm. Comparison of the activity (E) and chronicity (F) indices of kidneys after three weeks of sEHI (n = 8) and PEG treatment (n = 8) of mice in the therapeutic setting. Boxplots show medians and interquartile ranges; whiskers, range; light grey, PEG treatment; dark grey, sEHI treatment; *p < 0.05. Compared using Mann Whitney test.