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. 2019 Jun 20;9:8993. doi: 10.1038/s41598-019-45299-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of metabolic changes in sEHI- and PEG-treated NZB/W F1 mice in the kidneys and spleen. To visualise changes due to sEH inhibition, the values are displayed as ratios (sEHI group/PEG group); consequently, a ratio >1 indicates an increased amount of that metabolite, while a ratio <1 indicates a decreased amount, compared to the PEG group. Significant differences between groups are measured by Mann Whitney test and are indicated by asterisks. Light grey, prophylactic setting (4 weeks sEHI exposure before onset of proteinuria); dark grey, therapeutic setting (3 weeks sEHI exposure after onset of proteinuria); *p < 0.05; **p < 0.01.