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. 2019 Jun 20;9:8827. doi: 10.1038/s41598-019-45126-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Innate immunity genes in CHO cells are activated by poly I:C. (A) IFN-stimulated transcription was increased in cells treated with poly I:C /LyoVec for 24 h, but not with other TLR ligands engaging TLR9, TLR4 or TLR7/8. (B) Poly I:C triggered STAT1 phosphorylation when used at 1 g/L, and (C) the levels of Mx1 protein expression were comparable to those triggered by IFNα2c. Note that, the antibodies used here and the assay procedures are detailed in the Methods section. (D) Several pathways and processes were enriched for differentially expressed genes following poly I:C treatment (m vs. p). (E) Top upstream regulators that are activated (red) or repressed (blue) following poly I:C treatment. All full-length blots are presented in the Supplementary Fig. S12.