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. 2019 Jun 20;9:8827. doi: 10.1038/s41598-019-45126-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Poly I:C pre-treatment prevents virus infection of VCV, EMCV, and Reo-3. (A–C) Cell morphology (left panels) and cytopathic effect measured by crystal violet staining (right panels) of virus-infected CHO cells; (D) The enriched down-stream pathways under condition of Vm vs. Vp using RNA-Seq data. (E) The top 35 upstream regulators that are activated or repressed by poly I:C pre-treatment. A full list of the activated or repressed upstream regulators is shown in the Table S5.