Table 2.
The downstream effects of the upstream regulators from the comparison of m vs. p.
| Virus | Consis-tency score*a | Total nodes (TF, TG, BP) | Transcription factors (TF)*b | Target gene (TG)*c | Biological Process (BP)*d | Relations*e |
|---|---|---|---|---|---|---|
| 30 h | 5.82 |
21 (5, 13, 3) |
STAT1, IRF3, IRF5, IRF7, NFATC2 | CASP1, CXCL10, DDX58, EIF2AK2, IFIH1, IL15, ISG15, Mx1/Mx2, OASL2, PELI1, PML, SOCS1, TNFSF10 |
Inhibit Replication of virus. Activate Activation of phagocytes; Apoptosis of antigen presenting cells. |
6/15 (40%) |
| 54 h | 22.47 |
48 (7.29.12) |
STAT1, IRF3, IRF5, IRF7, NFATC2, TRIM24, NCOA2 |
BST2, C3, CASP1, CXCL10, DDX58, EGR2, EIF2AK2, GBP2, IFIH1, IFIT1B, IFIT2, IFITM3 (IITMP3), Igtp, IL15, ISG15, Mx1/Mx2, MYC, OASL2, PML, PSMB10, PSMB8, PSME2, PTGS2, SPP1, STAT2, TAP1, TLR3, TNFSF10, TRAFD1 |
Inhibit Replication of virus; Infection by RNA virus; Infection of central nervous system. Activate Antiviral response; Clearance of virus; Immune response of antigen presenting cells; Immune response of phagocytes; Cytotoxicity of leukocytes; Function of leukocytes; Infiltration by T lymphocytes; Quantity of MHC Class I of cell surface; Cell death of myeloid cells. |
21/84 (25%) |
| 78 h | 27.80 |
30 (8, 14, 8) |
STAT1, IRF5, NFATC2, NR3C1, PPARD, ZBTB16, CDKN2A, EBF1 |
C3, CCL2, CCL7, CD36, CXCL10, CXCL9, DDX58, EIF2AK2, ISG15, MYC, THBS1, TLR3, TNFSF10, VEGFA |
Activate Activation of macrophages; Apoptosis of myeloid cells; Cell movement of T lymphocytes; Cellular infiltration by leukocytes; Damage of lung; Recruitment of leukocytes; Response of myeloid cells; Response of phagocytes. |
11/64 (17%) |
| 78 h | 7.56 |
12 (2, 7, 3) |
CDKN2A, ZBTB16 | C3, CCL2, CCL7, CXCL10, CXCL9, MYC, VEGFA |
Activate Cell movement of T lymphocytes; Recruitment of leukocytes; Survival of organism. |
1/6 (17%) |
*aConsistency score is to measure the consistency of a predicted network by IPA with the literature evidences.
*b,cThe upstream regulators (STAT1 is highlighted in bold face) and the antiviral relating genes.
*dThe biological functions known to associated with the regulatory networks annotated by the IPA.
*eThe number of identified relationships and the total relationships that represent the known regulatory relationships between regulators and functions supported by literatures annotated by the IPA.