Table 3.
The downstream effects of the upstream regulators from the comparison of Vm vs. Vp.
| Virus | Consis-tency score | Total nodes (TF, TG, BP)*a | Transcription factors (TF) *b | Target genes (TG)*c | Biological Process (BP)*d | Relations*e |
|---|---|---|---|---|---|---|
| VSV | 8.00 |
22 (4, 15, 3) |
STAT1, IRF3, IRF5, IRF7 | CXCL10, DDX58, EIF2AK2, IFIH1, IL15, ISG15, JUN, Mx1/Mx2, OASL2, PSMB10, PSMB8, PSMB9, SOCS1, TAP1, TNFSF10 |
Inhibit Replication of virus; Quantity of lesion. Activate Quantity of CD8+ T lymphocyte. |
2/12 (17%) |
| EMCV | 12.16 |
29 (6, 19, 4) |
STAT1, IRF3, IRF5, IRF7, TRIM24, ATF4 | BST2, CXCL10, DDX58, EIF2AK2, EIF4EBP1, IFIH1, IL15, ISG15, Mx1/Mx2, OASL2, PSMB10, PSMB8, PSMB9, SLC1A5, SLC3A2, SLC6A9, SLC7A5, TAP1, TNFSF10 |
Inhibit Replication of virus; Transport of amino acids. Activate Quantity of CD8+ T lymphocyte; Quantity of MHC Class I on cell surface. |
3/24 (13%) |
| EMCV | 7.91 |
18 (2, 10, 6) |
CCND1, SMAD4 | AREG, CCND2, EREG, GJA1, HSPA8, ITGAV, NFKBIA, PTGS2, SOX4, SPP1 |
Inhibit Arthritis; Cell cycle progression; Cell viability; Growth of ovarian follicle; Proliferation of cells. Activate Edema. |
7/12 (58%) |
| EMCV | 6.96 |
19 (2, 10, 7) |
MKL1, VDR | CAMP, CCL2, HLA-A, ICAM1, IL6, MMP9, PTGS2, RELB, SPP1, TNC |
Inhibit Cancer; Quantity of interleukin; Rheumatic Disease; Development of body trunk. Activate Cell death of connective tissue cells; Nephritis; Organismal death. |
7/14 (50%) |
| Reo-3 | 5.61 |
21 (4, 14, 3) |
GFI1, NR1H3, NRIP1, PPARG | ACACB, CAV1, CD36, CSF3, ETS1, ID2, IL6, LDLR, LPL, NFKBIA, PDK2, PDK4, PPARA, SLC2A1 |
Inhibit Oxidation of carbohydrate; Production of leukocytes; Quantity of vldl triglyceride in blood. |
1/12 (8%) |
*aConsistency score is to measure the consistency of a predicted network by IPA with the literature evidences.
*b,cThe upstream regulators (STAT1 is highlighted in bold face) and the antiviral relating genes.
*dThe biological functions known to associated with the regulatory networks annotated by the IPA.
*eThe number of identified relationships and the total relationships that represent the known regulatory relationships between regulators and functions supported by literatures annotated by the IPA.