Table 1.
Clinical characteristics of the study cohort with CKD-MBD.
| Entire Study Cohort (n=58) | Subgroups by Turnover | Reference (peak bone mass) | |||
|---|---|---|---|---|---|
| High turnover (n=39) | Normal turnover (n=4)§ | Low turnover (n=15) | |||
| Αge (yrs) | 56 (45; 67) | 55 (40; 64) | 63 (52; 71) | 62 * (53; 75) | --- |
| Μale/female (nb.) | 27/31 | 17/22 | 0/4 | 10/5 | --- |
| HD or PD (nb.) | 42 | 31 | 2 | 9 | --- |
| duration of dialysis (months) | 56 (21; 81) | 55 (27; 83) | 70 (16; 123) | 57 (21; 78) | --- |
| Cinacalcet (nb.) | 25 | 23 | 1 | 1 | --- |
| Phosphatebinder (nb.) | 29 | 26 | 1 | 2 | --- |
| Patients with fx (nb.) | 14 | 4 | 4 | 6 | --- |
| Patients with PTX (nb.) | 9 | 5 | 0 | 4 | --- |
| Biochemical1 | |||||
| PTH (pg/ml) | 264 (75; 826) | 475 (156; 1047) | 64 (62; 345) | 90 ** (40; 189) | 10-65 |
| APH (µmol/l×s) | 1.9 (1.6; 2.8) | 2.1 (1.6; 2.9) | 1.2 (1.2; 2.6) | 1.9 (1.1; 2.9) | 0.6-2.20 |
| Ca (mmol/l) | 2.34 (2.24; 2.52) | 2.35 (2.26; 2.52) | 2.24 (1.84; 2.32) | 2.38 (2.23; 2.63) | 2.2-2.65 |
| 25OHD3 (nmol/l) | 64 (36; 90) | 63 (37; 90) | 119 (63; 175) | 65 (22; 83) | 75-375 |
| Phosphate (mmol/l) | 1.58 (1.12; 1.92) | 1.63 (1.21; 2.00) | 1.14 (1.06; 1.43) | 1.44 (0.97; 2.00) | 0.76-1.37 |
| Histomorphometric[2 | |||||
| BV/TV (%) | 16.6 (10.3; 21.8) | 17.4 (11.0; 21.7) | 14.5 (5.7; 21.1) | 16.10 (9.60; 22.70) | 20.43 (4.0) |
| OS/BS (%) | 3.7 (0.6; 11.9) | 6.1 (3.4; 17.5) | 1.0 (0.2; 6.4) | 0.00 (0.00; 0.40) | 14.3 (3.0) |
| Ob.S/BS (%) | 3.4 (0.3; 8.3) | 5.1 (3.3; 14.2) | 1.4 (0.8; 1.9) | 0.00 (0.00; 0.00) | 4.5 (3.2) |
| ES/BS (%) | 15.1 (10.0; 26.3) | 21.8 (13.3; 30.3) | 12.4 (10.6; 32.8) | 7.20 (4.20; 10.40) | 6.1 (1.9) |
| Oc.S/BS (%) | 3.3 (0.2; 9.2) | 6.8 (3.2; 13.3) | 1.4 (0.3; 2.0) | 0.0 (0.0; 0.0) | 2.5 (1.5) |
Data shown are median (25th; 75th percentiles) or mean (SD).
Abbreviations: nb.= number of patients; HD = hemodialysis; PD = peritoneal dialysis; PTX = parathyroidectomy; PTH = parathyroid hormone, APH = alkaline phosphatase, Ca = calcium, 25OHD3 = 25-hydroxyvitamin D3; BV/TV = bone volume per tissue volume, OS/BS = osteoid surface per bone surface, Ob.S/BS = osteoblast surface per bone surface; ES/BS = eroded surface per bone surface; Oc.S/BS osteoclast surface per bone surface; nomenclature according to Parfitt et al[49.
no statistical comparison due to small sample size
p<0.01,
p<0.05 low versus high turnover (adjusted for age if appropriate)
1 Biochemical information was not available from all patients;
2 No statistical comparison between bone turnover groups as histomorphometry was used to define bone turnover status.
3 Reference data are from a previous work by Delling[18.