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. 2019 Jun 14;10:736. doi: 10.3389/fphys.2019.00736

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Copyright © 2019 Møller, Vendelbo, Schjerling, Couppé, Møller, Kjær, Hansen and Jessen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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4EBP1 phosphorylation decreases during immobilization. mTOR phosphorylation at Ser²⁴⁴⁸ did not change during immobilization or rehabilitation (A). In accordance, the mTORC1 substrates 4EBP1 phosphorylation Thr^37/46 and p70S6K Thr³⁸⁹ remained unchanged during rehabilitation and rehabilitation (B,C). Values are geometric means ± back transformed SE. Representative western blots (D). Based on the applied molecular standards, approximated molecular weights are indicated on the right. Filled symbols represent subjects from T0 and open symbols represent subjects from T2.