Table 3. Multivariable Regression Models Predicting Global Neurocognitive Impairment^a.

Parameters	Global Neurocognitive Impairmentb
	RR (95% CI)	P Value
Propofol, per 100 mg/kg	1.40 (1.11-1.75)	.004
Fentanyl, per 10 μg/kg	1.20 (0.99-1.45)	.07
Midazolam hydrochloride, per 1 mg/kg	1.07 (0.42-2.73)	.89
Meperidine hydrochloride, per 1 mg/kg	0.98 (0.93-1.04)	.47
Morphine sulfate, per 1 mg/kg	0.70 (0.28-1.70)	.43
Pentobarbital sodium, per 10 mg/kg	1.02 (0.90-1.15)	.74
Glycopyrrolate, per 1 μg/kg	1.00 (1.00-1.01)	.14
Fluranes (per exposure)c	1.10 (1.01-1.21)	.03
Duration (per h)	1.03 (1.00-1.06)	.04

Abbreviation: RR, relative risk.

^aModels are adjusted for age at diagnosis, sex, total intrathecal chemotherapy count, and cumulative dose of high-dose intravenous methotrexate.

^bGlobal neurocognitive impairment is defined as 3 or more tests falling more than 2 standard deviations below the age-adjusted population normative means.

^cNumber of exposures was identified for fluranes because cumulative dose cannot be accurately captured for inhaled anesthetic agents.