Figure 1.

Establishment of PDX models from patients with CRLM. (A) A flow diagram described the steps taken to establish a stable PDX bank from patients with CRLM. (B) Latency period of CRLM PDX models was shorter with increasing passage. (C) The overall transplantation rates of CRLM at P3 were compared according to the sources of CRC tumor samples. (D) The relationship between the latency period and clinicopathological characteristics. Line and error bars represent median ± inter-quartile range. CRLM, Colorectal Cancer Liver Metastases; PT, Primary Tumor; LM, Liver Metastases; TRG, Tumor Regression Grading; Chemo, Chemotherapy; Meta, Metachronous; Syn, synchronous; WT, Wild Type; MT, Mutation; NS, Not Significant; * p < 0.05; ** p < 0.01; *** p < 0.001; ****p<0.0001 by one-way ANOVA, unpaired two-tailed t-test or chi-squared test.