Table 2.
Glomerular filtration rate (mL/min)
| n | Day 8 | Day 18 | Day 46 | |
|---|---|---|---|---|
| Control | 10 | 1.65±0.28 | 1.65±0.39 | 1.65±0.39 |
| AD-2K | 10 | 1.40±0.16 | 0.37±0.08a | 0.64±0.22a |
| AD-1K | 16 | 1.21±0.36 | 0.23±0.06a | 0.31±0.12a |
Values are presented as means ± standard deviation. AD-1K rats, rats with unilateral nephrectomy, adenine at 0.75% in the diet; AD-2K rats, sham-operated rats, adenine at 0.75% in the diet.
a
Significant difference versus control (p < 0.05); day –8 was used as baseline. Glomerular filtration rate was measured transcutaneously using fluorescein-isothiocyanate-labeled sinistrin as a tracer.