Table 3.
Histopathological findings
| Percentage of rats with pathological findings |
Semiquantitative mean severity score |
||||||
|---|---|---|---|---|---|---|---|
| control | AD-2K | AD-1K | control | AD-2K | AD-1K | ||
| Kidney | tubular dilatation/cysts | 0 | 100 | 100 | 0 | 2.7 | 3.9 |
| tubular degeneration/atrophy | 0 | 100 | 100 | 0 | 3.6 | 4.0 | |
| pelvic dilatation | 0 | 0 | 25 | 0 | 0 | 2.5 | |
| mineralization | 0 | 10 | 25 | 0 | 2.0 | 1.5 | |
| adenine crystals | 0 | 100 | 100 | 0 | 4.0 | 4.0 | |
| giant cells | 0 | 100 | 100 | 0 | 3.1 | 3.0 | |
| interstitial fibrosis | 0 | 100 | 100 | 0 | 3.1 | 3.1 | |
| mononuclear infiltration | 0 | 100 | 100 | 0 | 3.2 | 3.0 | |
| Heart | focal degeneration | 0 | 30 | 56.3 | 0 | 1.7 | 1.8 |
| vasculopathy | 0 | 0 | 43.8 | 0 | 0 | 1.4 | |
| Stomach | inflammatory infiltration | 0 | 0 | 6.3 | 0 | 0 | 1.0 |
| erosion | 0 | 0 | 6.3 | 0 | 0 | 1.0 | |
Percentages and scores indicative for higher incidence/severity in AD-1K rats are highlighted in bold. AD-1K rats, rats with unilateral nephrectomy, adenine at 0.75% in the diet; AD-2K rats, sham-operated rats, adenine at 0.75% in the diet.