Fig. 7.

Inhibition of autophagy by CQ abolishes the protective effects of TSA against cyst growth in Pkd1 knockout mice. Pkd1^−/− mice received CQ in the presence of TSA and were killed 25 days later; blood samples and kidneys were collected for biochemical and histological analyses. a 2KW/BW% and the number of proliferating cells. b Cystic area. Data are expressed as mean ± SD. * p < 0.05, ** p < 0.01 vs. TSA-only group. TSA, trichostatin A; CQ, chloroquine; 2KW/BW%, 2-kidney-weight/body-weight ratio.