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. 2019 Jun 3;74(1):184–193. doi: 10.1161/HYPERTENSIONAHA.119.13155

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© 2019 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Principal component analysis of plasma and fecal metabolites reveals a strong role for germ free status. Principal component analysis of metabolites in plasma (A) and feces (B) of conventional (Con) and germ-free (GF) mice treated with Ang II (angiotensin II) or saline (Sal). For both plasma and fecal metabolites, GF status played a stronger role than treatment status. For the plasma metabolites, differences were observed both in GF status and in sex.