Table 1.
Comparison of clinicopathological characteristics between EGFR mutation and EGFR wild-type cases with SqCC or NSCC favor SqCC diagnosed from small biopsies
| Characteristics | Total | EGFR mutation | EGFR wild-type | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. | % | No. | % | No. | % | |||||
| Number | 148 | 100.0 (148/148) | 13 | 100.0 (13/13) | 135 | 100.0 (135/135) | ||||
| Age(y) | P = 0.527 | P = 0.810 | ||||||||
| Median | 70.2 ± 12.4 | 67.5 ± 16.0 | 70.4 ± 12.1 | |||||||
| Range | 41–93 | 44–86 | 41–93 | |||||||
| Sex | P = 0.039* | P = 0.841 | ||||||||
| Male | 78 | 52.7 (78/148) | 3 | 23.1 (3/13) | 75 | 55.6 (75/135) | ||||
| Female | 70 | 47.3 (70/148) | 10 | 76.9 (10/13) | 60 | 44.4 (60/135) | ||||
| Smoking status | P < 0.0001* | P = 0.006* | ||||||||
| Never smoker | 39 | 30.5 (39/128) | 10 | 83.3 (10/12) | 29 | 25.0 (29/116) | ||||
| Smoker | 89 | 69.5 (89/128) | 2 | 16.7 (2/12) | 87 | 75.0 (87/116) | ||||
| Unknown | 20 | 1 | 19 | |||||||
| Biopsy method | P = 0.826 | |||||||||
| Bronchoscopic | 72 | 56.7 (72/127) | 6 | 50.0 (6/12) | 66 | 57.4 (66/115) | ||||
| CT-guided | 40 | 31.5 (40/127) | 4 | 33.3 (4/12) | 36 | 31.3 (36/115) | ||||
| Sono-guided | 15 | 11.8 (15/127) | 2 | 16.7 (2/12) | 13 | 11.3 (13/115) | ||||
| Unknown | 21 | 1 | 20 | |||||||
| Biopsy tissue | ||||||||||
| Average pieces | 4.4 ± 2.0 | 4.4 ± 2.2 | 4.4 ± 2.0 | P = 0.925 | ||||||
| Mean size (mm) | 6.6 ± 4.0 | 6.6 ± 3.3 | 6.6 ± 4.0 | P = 0.964 | ||||||
| Histological subtype | P < 0.0001* | P = 0.001* | ||||||||
| SqCC | 135 | 91.2 (135/148) | 7 | 53.8 (7/13) | 128 | 94.8 (128/135) | ||||
| NSCC favor SqCC | 13 | 8.8 (13/148) | 6 | 46.2 (6/13) | 7 | 5.2 (7/135) | ||||
*Statistically significant