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. 2019 Jun 21;17:77. doi: 10.1186/s12951-019-0509-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Two-step lipid–peptide conjugation through pyridyl disulfide reaction chemistry. Lipid activation (Step 1, left) DPTE lipid is activated with mercaptopyridine to avoid non-specific unwanted reaction products, i.e. the formation of the symmetric DPTE disulfide. Lipid bioconjugation (Step 2, right): the activated DPTE react with the sulfhydryl-group of the peptide of interest