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Synthesis of cyclo[DKP‐RGD]‐PEG4‐Val−Ala‐PABC‐Cry‐55gly (10), cyclo[DKP‐isoDGR]‐PEG4‐Val−Ala‐PABC‐Cry‐55gly (11), cyclo[DKP‐RGD]‐PEG4‐uncl‐Cry‐55gly (13), and cyclo[DKP‐isoDGR]‐PEG4‐uncl‐Cry‐55gly (14). Reagents and conditions: a) 7, DIPEA, DMF, RT, 4 h; b) cyclo[DKP‐RGD]‐PEG4‐N3, CuSO4 ⋅ 5H2O, sodium ascorbate, 1 : 1 DMF/H2O, 35 °C, 24 h; c) cyclo[DKP‐isoDGR]‐PEG4‐N3, CuSO4 ⋅ 5H2O, sodium ascorbate, 1 : 1 DMF/H2O, 35 °C, 24 h; d) 7, PyBOP, HOBt, DIPEA, DMF, RT, 4 h.
