Table 2.
microRNAs regulate PD-L1 expression.
| miR | Cell types | Regulation of PD-L1 | Targets | References |
|---|---|---|---|---|
| miR-106b | PDAC | − | − | (95) |
| miR-130b | CRC | + | PTEN | (99) |
| miR-135 | NSCLC | + | TRIM16/JAK/STAT | (98) |
| miR-138-5p | CRC | − | 3′-UTR | (101) |
| miR-140 | NSCLC | − | 3′-UTR | (102) |
| miR-140 | Osteosarcoma | − | 3′-UTR | (103) |
| miR-140 | Cervical cancer | − | 3′-UTR | (104) |
| miR-142 | Cervical cancer | − | 3′-UTR | (104) |
| miR-142-3p | Macrophage, DC | + | − | (105) |
| miR-142-5p | PDAC | − | 3′-UTR | (106) |
| miR-142-5p | NSCLC | − | PTEN/PI3K/Akt | (100) |
| miR-15a | MPM | − | 3′-UTR | (107) |
| miR-155 | HDLEC & DF | − | 3′-UTR | (108) |
| miR-16 | MPM | − | 3′-UTR | (107) |
| miR-16 | Macrophage | − | 3′-UTR | (109) |
| miR-17-5p | Melanoma | − | 3′-UTR | (110) |
| miR-18a | Cervical cancer | + | PI3K/AKT MEK/ERK Wnt/β-catenin/STAT3 P53/miR-34a |
(104) |
| miR-193a-3p | MPM | − | 3′-UTR | (107) |
| miR-195 | DLBCL | − | 3′-UTR | (111) |
| miR-197 | OSCC | − | − | (112) |
| miR-197 | NSCLC | − | STAT3 | (113) |
| miR-20b | CRC | + | PTEN | (99) |
| miR-200c | HCC | − | 3′-UTR | (114) |
| miR-200c | AML | − | 3′-UTR | (115) |
| miR-200c | NSCLC | − | 3′-UTR | (116) |
| miR-21 | Macrophage | − | JAK2/STAT1 | (117) |
| miR-21 | CRC | + | PTEN | (99) |
| miR-217 | Laryngeal cancer | − | Translation | (118) |
| miR-24 | Macrophage, DC | + | − | (105) |
| miR-30b | Macrophage, DC | + | − | (105) |
| miR-3127-5p | NSCLC | + | STAT3 | (97) |
| miR-33a | LA | − | 3′-UTR | (119) |
| miR-34 | NSCLC | − | 3′-UTR | (120) |
| miR-34a | Glioma | − | 3′-UTR | (121) |
| miR-34a | AML | − | 3′-UTR | (115, 122) |
| miR-340 | Cervical cancer | − | 3′-UTR | (104) |
| miR-375 | HNSCC | − | JAK2/STAT1 | (123) |
| miR-383 | Cervical cancer | − | 3′-UTR | (104) |
| miR-424(322) | Ovarian | − | 3′-UTR | (124) |
| miR-513 | Cholangiocytes | − | 3′-UTR | (125, 126) |
| miR-513a-5p | Retinoblastoma | − | 3′-UTR | (127) |
| miR-574-3p | Chordoma | − | − | (128) |
| miR-93 | PDAC | − | − | (101) |
−, negative; +, positive; PDAC, pancreatic ductal adenocarcinoma; CRC, colorectal cancer; NSCLC, non-small cell lung cancer; DC, dendritic cell; MPM, malignant pleural mesothelioma; HDLEC, human dermal lymphatic endothelial cell; DF, dermal fibroblasts; DLBCL, diffuse large B-cell lymphoma; OSCC, oral squamous cell carcinoma; HCC, hepatocellular carcinoma; AML, acute myeloid leukemia; LA, lung adenocarcinoma; HNSCC, head and neck squamous cell carcinomas; PTEN, phosphatase and tensin homolog; TRIM16, tripartite-motif 16; JAK, Janus kinase; STAT, signal transducer and activator of transcription; 3′-UTR, 3′ untranslated region; PI3K, phosphatidylinositol 3 kinase; AKT, protein kinase B;MEK, MAPK/ERK kinase; ERK, extracellular regulated protein kinases; P53, protein 53.