Figure 1.
The effect of CORM-A1 and DETA/NO in the experimental models of metastasis of 4T1-luc2-tdTomato cells. (A) Experiment schedules. Single doses of donors are indicated (CORM-A1 every 12h, DETA/NO every 24h). Colored circles correspond to indications in Scheme 1A. (B) Number of lung metastatic foci or fluorescence intensity of the lung (last column). (C) Endothelin 1 (ET-1) plasma level. (D) CD42b and (E) P-selectin positive platelets assessed by flow cytometry. Data presented as mean with standard deviation with points for individual measurements. Number of mice: 5-10 per group, some analyses were performed on randomly selected mice within the group. Healthy mice used as a control: 4-5. Statistical analysis: (B) Sidak's, (C) Dunnett's, (D) and (E) Dunn's multiple comparison tests. *p< 0.05 as compared to control or as indicated.