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. 2019 May 31;9(13):3918–3939. doi: 10.7150/thno.31461

Figure 3.

Figure 3

The impact of CORM-A1 and DETA/NO on blood biochemical parameters in the experimental models of metastasis of 4T1-luc2-tdTomato cells. (A) Nitrite, (B) carboxyhemoglobin (COHb), (C) Alanine aminotransferase (ALT), (D) aspartate aminotransferase (AST), (E) creatinine (CRE2), (F) urea (URE), (G) creatinine kinase (CK) and (H) creatinine kinase MB isoform (CK-MB) plasma level. “L” means lower dose of CORM-A1 and DETA/NO (0.5 mg/kg/12h and 1.57 mg/kg/24h, respectively; treatment schedule indicated by yellow circle in Scheme 1A and Figure 1A). “H” means higher dose of CORM-A1 and DETA/NO (1.5 mg/kg/12h and 2.358 mg/kg/24h, respectively; treatment schedule indicated by green circle in Scheme 1A and Figure 1A). Data presented as mean with standard deviation with points for individual measurements. Number of mice: 4-5 per group. Statistical analysis: Sidak's multiple comparison tests. *p< 0.05 as compared to control or as indicated.