Figure 5.

Plasma level of selected molecules involved in endothelium dysfunction and platelets activation. Measured by ELISA kits: (A) Endothelin-1, (B) prostacyclin metabolite (C) TGF-β, (D) VCAM, (E) ICAM, (F) E-selectin, (G) TXB₂, (H) P-selectin, (I) vWf. Mice were inoculated with 4T1 cells into fat pad and 7 days later, when tumors were palpable, the i.p. administration of CORM-A1 (0.5 mg/kg, every 12 h) and DETA/NO (1.570 mg/kg, every 24h) started. Data presented as mean with standard deviation with points for individual measurements. Number of mice: 8-11 per group, some analyses were performed on randomly selected mice within the group. Number of healthy mice used as a control: 4-5. Statistical analysis: Dunnett's multiple comparison test. *p< 0.05 as compared to control or as indicated.