Figure 7.

Epithelial to mesenchymal transition markers in 4T1 tumor tissue. (A) E-cadherin, (C) N-cadherin, (F) α-SMA densitometric analysis (mean optical density of bands of protein tested to β-actin) and representative blots (B), (D), (G), respectively. (E) Calculated E:N-cadherin ratio. Mice were inoculated with 4T1 cells into fat pad and 7 days later, when tumors were palpable, the i.p. administration of CORM-A1 (0.5 mg/kg, every 12 h) and DETA/NO (1.570 mg/kg, every 24h) started. Data presented as mean with standard deviation with points for individual measurements. Analyses were performed on tumors from randomly selected four mice within the group. Statistical analysis: Dunnett's multiple comparison test. *p<0.05 as indicated.