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. 2019 May 31;9(13):3918–3939. doi: 10.7150/thno.31461

Scheme 2.

Scheme 2

Mechanism of antimetastatic action of CORM-A1 + DETA/NO combined therapy. In the diagram, the upper arrow (I) indicates early stages of progression of 4T1 mammary gland cancer, the lower arrow (II) shows a later stage (after day 21). The descriptions in the bottom panel refer to the changes observed at earlier stages of cancer progression under the influence of combined therapy using CO and NO donors.