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. 2019 May 31;9(13):3966–3979. doi: 10.7150/thno.32172

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Increase in (A) TNF-α, (B) IL-6 and (C) IL-8 in the blood samples of mice at 6 h after HIFU tumor ablation. (D) Increased expression of VCAM-1 in tumor vasculature at 6 h after HIFU tumor ablation (red signal, VCAM-1; blue signal, cell nucleus; green signal, CD31). The scale bar represents 200 μm. (E) Fluorescence images of HeLa cell tumor-bearing mice at 2 h after intravenous injection of different vesicles when the tumors were pretreated with HIFU ablation. (F) Targeting efficiency of different vesicles to HeLa cell tumors pretreated with or without HIFU ablation.