Scheme 1.

Schematic design of temperature-sensitive plateletsomes (TSPs) as a tailored chemotherapy platform in combination with HIFU tumor ablation. (A) Main preparation process of drug-loaded TSPs: i) extraction of the PM from isolated PLTs; ii) preparation of TSPs by fusing the PM with MSPC and DPPC, followed by extruding the fused PM through 100-nm pores; iii) loading of doxorubicin (DOX) into TSPs. (B) DOX-loaded TSPs (DTSPs) could target cancer cells via the specific affinity between P-selectin and CD44 receptors, rapidly release the drug under HIFU hyperthermia, and implement highly efficient chemotherapy in combination with HIFU tumor ablation. (C) DTSPs can efficiently target postoperative tumor sites driven by HIFU-induced vascular damage and inflammation to implement ideal consolidation chemotherapy.