Table 1.

Correlation between FOXK2 expression and clinicopathological characteristics of CRC in two independent cohorts of human CRC tissues

Clinicopathological variables		Cohort I (n=363)		P value		Cohort II (n=390)		P value
		Tumor FOXK2 expression				Tumor FOXK2 expression
		Low (n=219)	High (n=144)			Low (n=232)	High (n=158)
Age		66.57(11.12)	65.88(11.70)	0.473		67.50(12.02)	67.47(10.87)	0.356
Sex	female	91	70	0.196		101	76	0.408
	male	128	74			131	82
Tumor location	right colon	98	75	0.006		87	78	0.025
	left colon	71	57			107	61
	rectum	50	12			38	19
Tumor size	<5 cm	93	61	1		93	56	0.396
	≥5 cm	126	83			139	102
Tumor differentiation	well or moderate	184	66	<0.001		159	65	<0.001
	poor	35	78			73	93
Tumor invasion	T1	6	1	0.014		14	2	0.021
	T2	25	5			13	11
	T3	141	101			166	107
	T4	47	37			39	38
Lymph node metastasis	absent	162	37	<0.001		185	41	<0.001
	present	57	107			47	117
Distant metastasis	absent	208	90	<0.001		222	96	<0.001
	present	11	54			10	62
AJCC stage	Stage I	31	4	<0.001		18	2	<0.001
	Stage II	131	28			167	32
	Stage III	46	58			38	63
	Stage IV	11	54			9	61